Normal global-local analysis in patients with dorsolateral frontal lobe lesions.

The role of prefrontal cortex in the analysis of global and local levels of a visual stimulus was assessed by measuring reaction time to identify a target at one level or the other. Unlike patients with temporal-parietal lesions (STG), there were no global-local performance deficits in right or left prefrontal groups (RFL or LFL). Reallocation of attention to global and local levels was measured by examining changes in performance when the probability of a target appearing at one level or the other varied. While patients with lateral parietal lesions (IPL) have been shown to have deficits in these conditions, both RFL and LFL showed normal changes in performance. In sum, the performance of prefrontal groups differed from both IPL and STG groups but not from normal controls. These results strengthen previous arguments that posterior association cortex is crucial in responding to global and local levels of a pattern.